INDUCIBLE MONOOXYGENASE ACTIVITIES AND 3-METHYLCHOLANTHRENE-INITIATED TUMORIGENESIS IN MOUSE RECOMBINANT INBRED SUBLINES
نویسندگان
چکیده
منابع مشابه
Inducible monooxygenase activities and 3-methyl-cholanthrene-initiated tumorigenesis in mouse recombinant inbred sublines.
The induction of a certain group of hepatic monooxygenase activities by polycyclic aromatic compounds is regulated by the same locus or gene cluster controlling the formation of cytochrome P1-450 (P-448) in mice. Certain inbred strains of mice are "responsive" (Ahb) to such induction, whereas others are "nonresponsive" (Ahd). A pair of closely related sublines that differ with respect to the Ah...
متن کامل3-methylcholanthrene-induced monooxygenase (O-deethylation) activity of human lymphocytes.
With a direct fluorescence assay, the levels of mixed-function oxidase activity were determined in mitogen-activated human lymphocytes. The O-deethylation of ethoxyresorufin to resorufin was used to quantitate mixed-function oxidase activity. Ethoxyresorufin O-deethylase activity was low to nondetectable in noninduced, mitogen-activated cells, but it was readily detected in 3-methylcholanthrene...
متن کاملAssociation between fighting behavior and catecholamine biosynthetic enzyme activity in two inbred mouse sublines.
Levels of three adrenal catecholamine synthesizing enzymes and isolation-induced fighting behavior were studied in two related sublines of the Balb/c inbred mouse strain. Enzyme levels were twice as high in the adrenals of Balb/cJ mice as in those of the Balb/cN mice; heterozygous progeny were intermediate between their parents in the levels of the three enzymes. These sublines also showed mark...
متن کاملAntibodies to spontaneous and methylcholanthrene-induced tumors in inbred mice.
Isoimmunity to a methylcholanthrene-indueed fibrosarcoma and to a spontaneous breast adenocarcinoma was induced in female O3H/HeX mice. Circulating antitumor antibodies spé cifie for the particular immunizing tumor were detected in the immune mice. These antibodies did not appear until the primary tumors were surgically removed. Measurable amounts of anti body could be detected as long as 3.5 ...
متن کاملSusceptibility of AKXD recombinant inbred mouse strains to lymphomas.
We analyzed the susceptibility of 10 AKXD recombinant inbred (RI) mouse strains to lymphomas. These strains were derived from crosses of AKR/J, a highly lymphomatous strain, and DBA/2J, a weakly lymphomatous strain. Of the 10 strains analyzed, nine showed a high incidence of lymphoma development. As with the other 13 AKXD strains analyzed previously (M. L. Mucenski, B. A. Taylor, N. A. Jenkins,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetics
سال: 1976
ISSN: 1943-2631
DOI: 10.1093/genetics/83.3.537